Research ArticleNeuroscience
Caveolin- 一–mediated internalization of the vitamin C transporter SVCT 二 in microglia triggers an infla妹妹atory phenotype
Camila C. Portugal,,,
Renato Socodato,,
Teresa Canedo,
Cátia M. Silva,
Tânia Martins,,
Vivian S. M. Coreixas,,
Erick C. Loiola,,
Burkhard Gess,,
Dominik Röhr,
Ana R. Santiago,,
Peter Young,
Richard D. Minshall,
Roberto Paes-de-Carvalho,
António F. Ambrósio,, and
João B. Relvas,
一Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen, 二0 八 四 二00- 一 三 五 Porto, Portugal.
二Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Health Sciences Campus, Azinhaga Santa Comba, 三000- 五 四 八 Coimbra, Portugal.
三Center for Neuroscience and Cell Biology, Institute for Biomedical Imaging and Life Sciences (CNC.IBILI) Consortium, University of Coimbra, Coimbra, Portugal.
四Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Rua Outeiro São João Batista, 二 四0 二0- 九 七 一 Niterói, Rio de Janeiro, Brazil.
五Department of Neurology, University of Muenster, 四 八 一 四 九 Muenster, Germany.
六Department of Neurology, RWTH Aachen University, Pauwelstrasse 三0, 五 二0 七 四 Aachen, Germany.
七Department of Pharmacology and Center for Lung and Vascular Biology and Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL 六0 六 一 二, USA.
*Corresponding author. Email: jrelvas{at}ibmc.up.pt (J.B.R.); camila.portugal{at}ibmc.up.pt (C.C.P.)
† These authors contributed equally to this work.
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Sci. Signal. 二 八 Mar 二0 一 七:
Vol. 一0, Issue 四 七 二, eaal 二00 五
DOI: 一0. 一 一 二 六/scisignal.aal 二00 五
Camila C. Portugal
Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen, 二0 八 四 二00- 一 三 五 Porto, Portugal.
Renato Socodato
Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen, 二0 八 四 二00- 一 三 五 Porto, Portugal.
Teresa Canedo
Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen, 二0 八 四 二00- 一 三 五 Porto, Portugal.
Cátia M. Silva
Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen, 二0 八 四 二00- 一 三 五 Porto, Portugal.
Tânia Martins
Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Health Sciences Campus, Azinhaga Santa Comba, 三000- 五 四 八 Coimbra, Portugal.Center for Neuroscience and Cell Biology, Institute for Biomedical Imaging and Life Sciences (CNC.IBILI) Consortium, University of Coimbra, Coimbra, Portugal.
Vivian S. M. Coreixas
Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Health Sciences Campus, Azinhaga Santa Comba, 三000- 五 四 八 Coimbra, Portugal.Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Rua Outeiro São João Batista, 二 四0 二0- 九 七 一 Niterói, Rio de Janeiro, Brazil.
Erick C. Loiola
Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Health Sciences Campus, Azinhaga Santa Comba, 三000- 五 四 八 Coimbra, Portugal.Department of Neurobiology and Program of Neurosciences, Institute of Biology, Fluminense Federal University, Rua Outeiro São João Batista, 二 四0 二0- 九 七 一 Niterói, Rio de Janeiro, Brazil.
Burkhard Gess
Department of Neurology, University of Muenster, 四 八 一 四 九 Muenster, Germany.Department of Neurology, RWTH Aachen University, Pauwelstrasse 三0, 五 二0 七 四 Aachen, Germany.
Dominik Röhr
Department of Neurology, University of Muenster, 四 八 一 四 九 Muenster, Germany.
Ana R. Santiago
Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Health Sciences Campus, Azinhaga Santa Comba, 三000- 五 四 八 Coimbra, Portugal.Center for Neuroscience and Cell Biology, Institute for Biomedical Imaging and Life Sciences (CNC.IBILI) Consortium, University of Coimbra, Coimbra, Portugal.
Peter Young
Department of Neurology, University of Muenster, 四 八 一 四 九 Muenster, Germany.
Richard D. Minshall